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In colorectal cancer, LPS binding to TLR4 similarly recruits and activates TRAF6, thereby stimulating the NF-B pathway, resulting in phosphorylation of p65/RelA and upregulation of VEGF-C expression, which in turn promotes lymphangiogenesis and lymphatic metastasis (123)

We have also showed that other markers of DNA damage/cell cycle (p21, p53, p57 and phospho-p57, GADD45, 8-OHdG), apoptotic (BCL-2, CASP-2, CASP-9) and anti-oxidant pathways (GP-1, SOD-1, HO-1, p38 stress kinase), that are not specifically associated with hair follicle pigmentation, have distinct expression patterns and colocalise to parts of the hair follicle such as the IRS, ORS, DP and cortex

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M3(R2) Non-clinical safety studies for the conduct of human clinical trials and marketing authorization for pharmaceuticals

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