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ALD is caused by mutations in ABCD1 , a gene located on the X chromosome that codes for ALD, a peroxisomal membrane transporter protein

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Single-cell RNA sequencing analysis revealed that the lipid oxidation activity of keratinocytes was closely related to the Th22/Th17 pathway, and lipid peroxidation in keratinocytes was also found to be enhanced during the course of psoriasis (Shou et al., 2021)