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Their low bioavailability, short half-life in the body, and complex metabolic conversion make it difficult to achieve effective therapeutic concentrations ( in vivo even when concentrations are extremely low, facilitating a more precise evaluation of their bioavailability ( Current reviews mainly focus on the impacts of particular subclasses of flavonoids or their effects within particular disease contexts, while a holistic perspective is absent

Once outside the cell, glutathione (GSH) degradation occurs exclusively in the extracellular space, and only on the surface of cells that express the ectoenzyme -glutamyl transferase

In COPD, YTHDF1 facilitates the translation of IREB2 (Iron-responsive element-binding protein 2), consequently inducing ferroptosis [58]

Out of all genomic regions, long read sequencing provides advantages in studying repetitive elements, which are difficult to characterize through other sequencing methods

Cellular metabolites and drug byproducts often complicate chemotherapy efficacy with poorly defined molecular mechanisms 20,21,22,23