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Effectiveness of lifestyle interventions for individuals with severe obesity and type 2 diabetes: results from the Look AHEAD trial

It also chelates metal ions, particularly copper and iron, which contribute to oxidative stress and A aggregation in AD

Besides, berberine inhibits the p-ERK/Eukaryotic translation initiation factor 2alpha (eIF2) pathway and then reduces BACE1 expression, the decrease in BACE1 protein expression inhibits the production of A