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Physiologically, various signals, including endoplasmic reticulum stress (ERS), VEGF, IL-6, macrophage colony-stimulating factor (M-CSF), IL-3, IFN-, thrombopoietin (TPO), GM-CSF, receptor tyrosine kinase (c-Kit) ligands, lipopolysaccharide (LPS), FMS-like tyrosine kinase 3 ligands (FLT3L), and IL-1, with GM-CSF upregulate and mediate the differentiation of MDSCs [299, 346]

doi: 10.1016/j.brainres.2016.09.035 114

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