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139 LiH.ZhaoJ.LaiL.XiaY.WanC.WeiS.et al (2022)

Clin Infect Dis 21(5):11141120 Rempe RG, Hartz AM, Bauer B (2016) Matrix metalloproteinases in the brain and bloodbrain barrier: versatile breakers and makers

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Embodiment 19: vitamin D3 is accredited as apparent metabolism and changes agent Vitamin D3 or 1 , 25-dihydroxy vitamin d3 (being also referred to as calcitriol) are from the synthetic vitamin D metabolites of vitamin D through two step enzymatic methods.Vitamin D3 and its omnipresence nucleus vitamin D receptor (VDR) interact to regulate the gene transcription of a series of participation calcium and phosphoric acid homoiostasis and cell division and differentiation.Reported vitamin D3 and in many model systems (comprising squamous cell carcinoma, adenocarcinoma of prostate, ovarian cancer, breast carcinoma and pulmonary carcinoma), had anticarcinogenic effect (summarizing 2007 Nature Reviews Cancer 7:684-700) in people such as Deeb