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Blood 109 , 40454054 (2007)

Patel BD, Welch AA, Ingham SA, Luben RN, Dayne, Khaw KT, Lomas DA, Wareham NJ

Its associated with significant brain damage and potentially life-threatening complications

Subsequent sections will provide a detailed analysis of how MPs/NPs exacerbate PD progression through specific pathways: promoting aberrant -synuclein aggregation, inducing neuroinflammation, disrupting gut-brain axis homeostasis, interfering with mitochondrial energy metabolism, inhibiting the excitatory amino acid transporter 2(EAAT2), and triggering ferroptosis

499 A and phosphorylated Tau (p-Tau) neurofibrillary lesions lead to the pathology of neurons that display oxidative damage, impaired Ca2+ processing, reduced DNA repair, dysfunction of lysosomal and mitophagy, all of which have a positive correlation with the age-related NAD + decline