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For instance, while REW-containing IgG2 is equipped with the capacity to mediate induction of classical complement activation, IgG4 REW remains inert in this regard, which is a differentiator compared to other reported Fc-engineered strategies

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Mitochondrial oxidative stress in the retinal pigment epithelium (RPE) led to metabolic dysfunction in both the RPE and retinal photoreceptors

1 to provide an overview of the study design and experimental setup