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Integrating these datasets with plasma proteomics and metabolomics from exercise-intervened diabetic cohorts could reveal receptor-ligand interactions connecting exerkines to retinal signaling pathways and identify convergent exerkine nodes within inflammatory, fibrotic, or angiogenic networks (271)

Direct interactions between RIPK3 and enzymes, such as the pyruvate dehydrogenase complex (PDH), glutamate-ammonia ligase (GLUL), glutamate dehydrogenase 1 (GLUD1), and glycogen phosphorylase L (PYGL), can enhance energy metabolism and promote mitochondrial ROS production, thereby augmenting necroptosis in cervical adenocarcinoma and colon cancer cells [134]

In vivo, PtCuO X /CeO 2X nanozymes inhibited the ROS/Rac-1/NF-B signaling pathway to remodel the OA therapy (Fig

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