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AIs target the aromatase enzyme [cytochrome P450 19A1 (CYP19A1)], which is responsible for catalyzing the transformation of C19 androgens (TST and ASD) into C18 estrogens (E1 and E2) via aromatization in the endoplasmic reticulum, as illustrated in Figure 4

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The increased cost reflects the longer treatment time, medical supplies, nursing oversight, and the ability to include multiple nutrients in one session