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Cuprizone intoxication induces cell intrinsic alterations in oligodendrocyte metabolism independent of copper chelation

ROS promotes Th17 differentiation and IL-17 production through activation of the RORt and STAT3 pathways

In support of synergistic interactions, Bassil and colleagues demonstrated that the unilateral hippocampal injection of mouse syn PFF (mPFF) into the aggressive 5xFAD amyloid model leads to more severe and widespread syn pathology, hyperphosphorylated tau detection, hippocampal and midbrain neuronal loss, and cognitive and motor deficits [217]

The discrimination among the substrates almost exclusively favor 5-AD for HsaGST A3-3 and EcaGST A3-3, whereas trans -2-nonenal is a signature substrate for HsaGST A4-4

This study further supports that this local destabilization is dependent on the nature of a non-polar branched or medium-long aliphatic amino acid side chain