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Preclinical studies using AD mouse models have highlighted that hyperphosphorylated tau is associated with cognitive impairment (Rowe et al., 2007

Tao L, Zhou K, Zhao Y, Xia X, Guo Y, Gao Y, et al

Human clinical and epidemiological evidence While numerous mechanistic studies have clarified the molecular pathways linking diabetes to impaired spermatogenesis, growing clinical and epidemiological evidence also supports this association in human populations

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M., Carmichael, R