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256 Mutations in Fbw7, observed in breast and ovarian cancers, lead to cyclin E accumulation, premature S-phase entry, chromosomal instability, and tumor formation

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238,239,240 Unlike in murine hepatocytes, the Wnt/-catenin pathway plays an indispensable role in the mitosis of human hepatocytes

Studies show that A induces GSH depletion in cultured neurons, whereas supplementation with -glutamyl-L-cysteinyl-glycine ethyl ester (GCEE) restores intracellular GSH levels and suppresses A-induced neurotoxicity (289)

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