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To isolate the metabolic effects of the transcriptional status of HIV1, we focused on the role of the lentiviral transactivator Tat protein, which is required for the expression of the integrated provirus through binding to the transactivation response (TAR) region, but can also activate numerous cellular genes and molecular networks, especially those involved in inflammatory responses (Clark et al , 2017)

[0319] As indicated above, in various embodiments, the antibody binds (e.g., specifically binds ALPP and/or ALPPL2 (see, e.g., Fig 1 for ALPP and ALPPL2 sequences)

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The importance of ferroptosis in neurodegenerative diseases extends beyond being merely a marker of pathology