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Interestingly, the enzyme is nine times more active with S -phenylcysteine sulfoxide than with S -phenylcysteine

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While antioxidant-based therapies can alleviate disease progression, our findings propose a distinct therapeutic paradigm: actively inducing ferroptosis by disrupting endogenous defense mechanisms

Importantly, OxD for both sensor variants can be converted to the respective redox potential and in both cases the redox potential is about 260 mV