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However, Huberman is still on the fence about the long-term use of rapamycin, particularly due to its immune-suppressing properties at higher doses

In vitro experiments demonstrated that NNMT overexpression significantly increased Sirt1 protein expression in primary hepatocytes, while NNMT knockdown led to a notable decrease in Sirt1 protein expression

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The compound is not intended for administration to humans or animals outside of formally approved preclinical study frameworks