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Paeoniflorin attenuates hepatic ischemia/reperfusion injury via anti-oxidative, anti-inflammatory and anti-apoptotic pathways

Specifically, free ferric iron is shuttled into cells bound by transferrin (TF), and reduced to ferrous iron via catalyzing by endosomal six-transmembrane epithelial antigen of prostate 3 (STEAP3), subsequently ferrous iron is released into the cytoplasm through divalent metal transporter 1 (DMT1) to expand the labile iron pool (LIP) (Xu et al., 2024)

Bnfi, P.B

Specifically, dysregulated neuronal energy metabolism can trigger apoptotic cascades via mitochondrial membrane potential collapse or abnormal pyruvate dehydrogenase complex phosphorylation, while targeting monocarboxylate transporter MCT2-mediated lactate shuttling or mitochondrial calcium uniporter (MCU) activity has emerged as a promising therapeutic strategy for neurodegenerative disorders

Plant Growth Regul 16(3):249252