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Free duodenal vitamin B 12 binds to intrinsic factor (IF) [28], with the vitamin B 12 IF complex binding in a calcium-dependent manner to the cubilin receptor on enterocytes in the distal ileum, resulting in receptor-mediated endocytosis and vitamin B 12 absorption

As a naturally occurring peptide fragment, BPC-157 also lacks strong patent protection, which has likely reduced commercial incentive to fund the trials needed for FDA approval

80 A means of resolving this situation is provided by studies which have shown that malabsorption of vitamin B 12 induced by metformin can be reversed by oral supplementation of vitamin B 12, even whilst metformin treatment is continued

The purification regime is briefly described as follows

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