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However, when present in normal concentrations, A does not induce oxidative stress, but when the amount of A increases significantly, as it does in AD, it evolves into a pro-oxidant that enhances oxidative stress, leading to disease progression (Rani et al., 2017)

Liposomal Delivery Systems for Antioxidant Nutrients: Technological Advances and Clinical Applications

In general, ECs are connected side-by-side through transmembrane adhesion proteins [37], including vascular endothelial and neural cadherin at adherent junctions [38, 39], occludin [40], and members of the claudin family [41], as well as the junctional adhesion molecule (JAM) family at tight junctions [42]

Indeed, GSH is involved in protection against oxidative stress and the elimination of heavy metals and toxic endogenous metabolites, and it is also a source of cysteine

doi: 10.1016/j.tcm.2016.03.001 342 ShaoXMLpez-ValdsHELiangJFeldmanJL