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Conclusions Nrf2 is a master regulator of several protective stress response pathways and it is not surprising that it became a highly competitive target for pharmacological modulation (Cuadrado et al

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While experimental and computational studies suggest that both the sulfur and selenium variants proceed through a double [2,3]-sigmatropic rearrangement, the sulfenylation reagents behave as coupling partners while organoselenium reagents can be employed catalytically