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The Gastrointestinal System Is Disturbed Nicotine also affects the stomach and digestive system, often causing these troublesome symptoms: Indigestion and heartburn Nausea and vomiting Diarrhea Peptic ulcers Dry mouth Similar to the negative effects on your hormones and brain, nicotine can cause you to feel physically ill

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Areas like South Asia, where smokeless tobacco products have deep cultural roots, still account for a major share

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Other reviews gave risk estimates for only one or two regions