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The deposition of immune complexes and the resultant local inflammatory responses establish an autoimmune cycle, continuously stimulating the activation of T cells and B cells, thereby exacerbating tissue damage and inflammation (27)

The construct targets cartilage, improves cellular uptake, scavenges excess ROS, and promotes stem-cell chondrogenic differentiation

Deferoxamine inhibits iron-uptake stimulated osteoclast differentiation by suppressing electron transport chain and MAPKs signaling

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If the compound binds to the receptor, the binding of labeled ligand to the receptor is inhibited as determined by a reduction of labeled ligand which binds to the receptors