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Cited 8/3/24 Vanderah TW (2024): Cholinoceptor-Activating & Cholinesterase-Inhibiting Drugs

J.BonillaI

Moreover, the fatsoluble vitamin influences the human microbiota by retaining intestinal homeostasis accomplished due to an increased cellular production of antimicrobial proteins from, for example macrophages and monocytes through RXR/VDR-signaling induction of promotor sequences of cathelicidin antimicrobial peptide etc., thereby preventing intestinal bacterial translocation and, on a large scale, the development of auto-inflammatory / metabolic dysfunctions, along with its role in maintaining intestinal epithelial cell integrity (production of nitric oxide due to upregulation of endothelial nitric oxide synthase (eNOS)), which in turn minimizes epithelial damage caused by bacterial lipopolysaccharides (LPS) [151, 162,163,164,165,166,167,168]

Mohar, I

Mechanistic studies reveal that inflamed intestinal tissues in IBD patients and corresponding animal models display characteristic ferroptosis features, including GSH depletion, suppression of GPX4 activity, and abnormal iron deposition