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There is an association between ROS and HCV disease activity

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In the case a protein is oxidatively modified/damaged by ROS in an ongoing process, it undergoes a transition from slight functional decrease and increased solubility to a completely dysfunctional, unfolded, and insoluble structure that may be even resistant to mammalian proteases due to covalent cross-linking, depending on the amount of oxidative modification [167]

One study found that mice treated with 5-Amino-1MQ had significantly lower body weight, smaller fat cells, and less overall fat mass than untreated mice , despite no difference in food intake

At the same time, the bacteria infection caused by the intracellular accumulation effect can be achieved by adjusting B-lymphoma-2 (Bcl-2) family protein expression or inactivated retinoblastoma inhibitory protein to inhibit apoptosis and promote the transformation of cancer cells (Cui et al., 2018)