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In biological systems, this lack of binding affinity prevents rapid clearance, resulting in a half-life approximately 120 times longer than endogenous IGF-1

(PubMed) Almeida OP, Ford AH, Hirani V, et al

Once the therapeutic effect begun, the therapeutic effect is continuous, and neither of the continuous ligation-induced disturbances reappeared (Vukojevic et al., 2018