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[Google Scholar] 43.Niss O, Chonat S, Dagaonkar N, et al

b: Comparisons between diseased control with standard methotrexate (0.1 mg/kg, i.p.) and EEMS (100, 200, 400 mg/kg) treated groups

Several studies have demonstrated that NAD + metabolism is involved in neuronal function and in the pathophysiology of neurodegenerative diseases (Hikosaka et al., 2019) and that NAD + levels in tissues can produce beneficial therapeutical effects in this type of diseases (Kulikova et al., 2018)