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Kee et al., 2023) and meta-analyses reinforces that genetic differences in drug-metabolizing enzymes directly influence plasma concentrations and clinical outcomes, with poor metabolizers tending toward higher exposure and potential toxicity, and ultrarapid metabolizers often demonstrating underexposure and poor therapeutic response

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After incubation for different times, the sample was centrifuged (10,000 g , 15 min) and 50 L supernatant was taken to mix with 100 L Ti(SO 4 ) 2

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