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A marked depletion of beneficial taxa was identified, including a significant reduction in Ligilactobacillusa probiotic genus important for mucosal immunityas well as a pronounced decrease in Butyrivibrio, a key butyrate producer essential for gut barrier integrity, and a substantial decline in [Eubacterium]_siraeum_group, which is involved in SCFA production

The malignant progression is accompanied with cytotoxicity decrease in NK cells and conversion to exhaustion due to changes in NK receptors, for example, the downregulation of NKG2D, NKp30, and DNAX accessory molecule-1 (DNAM-1) receptors

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