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An amide derivative 13d (Ca2+ flux IC50 = 188 nM, [brain]/[plasma] = 0.97 @ 8 h in rat), for example, showed a 10% decrease in 24-hour food intake in rats, and over 5% body weight reduction after 14-day oral treatment in diet-induced obese (DIO) mice (180)

[DOI] [PMC free article] [PubMed] [Google Scholar] 193.Beyer J.N., Serebrenik Y.V., Toy K., Najar M.A., Feierman E., Raniszewski N.R., Korb E., Shalem O., Burslem G.M

Furthermore, 13-HODE was also found to induce ROS and ER-stress in hepatocytes 42

Effects of Secreted Factors in Culture Medium of Annulus Fibrosus Cells on Microvascular Endothelial Cells: Elucidating the Possible Pathomechanisms of Matrix Degradation and Nerve In-Growth in Disc Degeneration

Oehlmann J, Schulte-Oehlmann U, Kloas W et al (2009) A critical analysis of the biological impacts of plasticizers on wildlife