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Given the wide variety of prescription, over the counter, and alternative treatments still currently being prescribed by physicians or sought independently by patients, there is a need to rigorously test new evidence-based therapeutic options for patients with persistent symptoms (187)

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However, due to the lack of clinically relevant models and expense of long-term testing, few studies have modeled antioxidant therapy for prevention of neurodegeneration

15, 18, 48 The colon in claudin-2 TG mice is significantly longer than that of their littermates and their colonic epithelial proliferation is also upregulated