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41,42 Elevated neuronal iron further reinforces Tau pathology via CDK5/P25 and GSK-3 signaling, while Fe 3 -histidine interactions perpetuate NFT formation

This broad regulatory activity includes upregulation of tissue repair genes, collagen synthesis pathways, antioxidant defense systems, and anti-inflammatory signaling networks, alongside simultaneous downregulation of genes associated with tissue destruction, inflammation, and fibrosis

A multivariate Cox proportional hazard regression analysis was performed to identify the independent risk factors of survive, based on which the prediction nomogram models were constructed and validated

Post-LT, 7 patients met the primary outcome (5.8%)

4.1.2 Dyslipidemia Dyslipidemia is a condition with an increased level of total or LDL cholesterol or a reduction in high-density lipoprotein (HDL) cholesterol level, leading to an imbalance of lipids (Pappan and Rehman, 2021) Increased endothelial ROS production is intimately linked to atherogenic dyslipidemia