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In line with the concept that T cell activation and differentiation require metabolic adaptation, SLC1A5 couples TCR and CD28 signals to ultimately activate the mTORC1 pathway and enable the cell to undergo clonal expansion (105)

Hum Mol Genet 19:37593770

Conversely, both groups analysed herein were different, as CD4 + and CD8 + T cells were not equally distributed, but at the respective proportion of 3:1

Joint Statement of the American Thoracic Society (ATS), the European Respiratory Society (ERS) and the World Association of Sarcoidosis and Other Granulomatous Disorders (WASOG) adopted by the ATS Board of Directors and by the ERS Executive Committee, February 1999