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Stampfer et al, 1992), cerebrovascular (Brattstrm et al, 1992

It is now clear that AngII interferes with performance by animal models of AD on most memory tasks while AngIV facilitates performance

or that systemic dosing is safer or more efficient than a serum

On the other hand, its high reactivity also contributes to the uncontrolled removal of electrons, which underlies pathological cell damage through the propagation of highly reactive oxygen-containing molecules

Given the limitations of current single-target therapies, interest has grown in natural products as promising multi-target agents for modulating AD pathology (Zhang et al., 2024)