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J Neurochem 12: 287309

It is due to the inactivation of the glutathione (GSH)-dependent antioxidant defense mechanism in cells, and the ability of GPX4 to suppress lipid ROS accumulation is inhibited, which eventually leads to lipid peroxidation and cell death (Dixon et al., 2012)

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Isr Med Assoc J 18(34):188192 De Berardis D, Orsolini L, Serroni N, Girinelli G, Iasevoli F, Tomasetti C, Mazza M, Valchera A et al (2015) The role of melatonin in mood disorders