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The treatment also appeared to ameliorate cardiovascular risk, as endothelial function improved by the end of the treatment period

Notably, the results demonstrated that UA exerts its effects by downregulating microtubule-associated proteins 1A/1B light chain 3B and Lysosomal-associated membrane protein 1 expression, without significantly altering PINK1 and Parkin protein levels (36)

The dose-normalized peak concentration decreased with dose escalation, indicating the capacity-limited non-linear pharmacokinetics of oral l-glutamine

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doi: 10.1111/jpi.12550 71 IshizukaBFusamaSHiraiKHosakaTHamadaNAmemiyaAet al