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It can trigger cellcycle arrest, repair or apoptosis

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In the UK, it accounts for 60% of the 1 billion National Health Service expenditure on COPD 14,15 , while in the USA it accounts for 13 billion USD 16

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This reduces tumor initiation ability while simultaneously increasing the expression of solute carrier family 7 member 11 (SLC7A11), which protects tumor cells from lipid peroxidation and ferroptosis that promote tumor metastasis

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Adult male 812 week-old hepsin / and wild-type mice, obtained from heterozygous inbreeding, were used throughout the study (Fig

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doi: 10.3390/toxins13120875

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