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Because no single buffer system can effectively maintain a constant pH value over the physiological range of approximately 5 to 7.4, biochemical systems use a set of buffers with overlapping ranges

For hair, PDRN is most useful in patients whose hair loss has an inflammatory or post-inflammatory component: telogen effluvium after stress, hair loss following autoimmune flares, recovery after hair transplant procedures, or scalp inflammation accompanying conditions like seborrheic dermatitis