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This is particularly relevant for metal-containing platforms (for example, ZIF-8), where ion release during degradation may perturb ionic homeostasis and inflammatory signaling, necessitating rigorous extractables and extended biocompatibility testing

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EMT-regulatory mechanisms may differ substantially among organs (lung, kidney, liver), and even within the lung, alveolar and bronchial epithelia display divergent responses and EMT potentials to TGF-

Molecules 26(18):5616