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Analysis of the crystallographic B-factors suggest that this loop is significantly more dynamic than the immediately surrounding regions of the PDO domain besides a solvent-exposed peripheral helical domain (Fig

Focus on FP: Clostridium mixtures ( FP , Bacteroides faecis, Roseburia intestinalis) restore the Treg/Th17 balance in DSS-induced UC mice, increase IL-10 and IL-4 secretion, reduce pro-inflammatory factors such as TNF, IL-1, and IL-17, and repair the intestinal barrier (104)

This approach may approximate the direct application scenario but poorly represents the pre-aged state of materials from indirect release pathways, which are arguably the more widespread source of environmental loading

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