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In a market-based economy, permissionless innovation allows entrepreneurs to create new products and to test those products in the marketplace.[61] If entrepreneurs think consumers want to buy something that is profitable for them to make, they ramp up production and sell their products

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[41] Exposure can be either active (smoking yourself) or passive (living in a house where someone else smokes)

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A mouse model for chronic intermittent electronic cigarette exposure exhibits nicotine pharmacokinetics resembling human vapers