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35 Senescent cells Cells are driven into a senescent, nondividing state by many factors, such as telomere shortening, DNA damage, oxidative stress, genotoxic stress, and altered chromatin structure

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The trauma activated pro-inflammatory cytokines as part of the healing cascade, and inflammation isnt fun to deal with

In order to sustain protection against persistent oxidant injury, GSH levels must be maintained, and this is accomplished by glutathione reductase (GSSG-R), which catalyzes reduction of GSSG to GSH