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Nat Rev Immunol 20 , 392394 (2020)

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The findings indicate that digestive diseases contribute significantly to the global healthcare burden, with over one-third of all cases having a digestive etiology worldwide (Wang F

Research suggests that some symptoms of NCGS may actually be mediated by histamine receptors

However, broader meta-analyses indicate: Berberine shows benefits on fasting glucose and HbA1c and can be comparable to metformin in some small trials, but effect sizes and study quality vary widely