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Additional studies are needed to evaluate for clinical features of vitamin B12 deficiency and hyperhomocysteinemia and determine if monitoring of vitamin B12 status and supplementation are warranted among RA patients treated with methotrexate and folic acid

Vitamin B12 for vision A rare condition from a lack of vitamin B12 is optic neuropathy

The histone methyltransferase enhancer of zeste homolog 2 (EZH2) is discovered to overexpress in RA FLS and can be induced by TNF- through the JAK and NF-B pathways

Stangl TA, Wiepjes CM, Smit RA et al (2024) Association between low sex hormone-binding globulin and increased risk of type 2 diabetes is mediated by increased visceral and liver fat: results from observational and Mendelian randomization analyses

Based on findings that cancer cells have limited capacity for recovering methylation units, Ulanovskaya et al