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Discuss the importance of having access to an opioid overdose reversal agent, especially if the patient has risk factors for overdose (e.g., concomitant use of CNS depressants, a history of opioid use disorder, or prior opioid overdose) or if there are household members (including children) or other close contacts at risk for accidental ingestion or opioid overdose

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Antacids and histamine-2-blocking agents are currently the cornerstones of effective prophylaxis, but because they have been linked to nosocomial pneumonias caused by bacterial overgrowth in the stomach, research into alternative prophylactic agents like sucralfate and prostaglandins that do not alter gastric acidity is ongoing