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Xanthine oxidoreductase is transformed by proteases into xanthine oxidase, which is then able to transfer electrons from xanthine to oxygen to generate ROS and participate in the inflammatory pathway by inactivating MAPK phosphatase-1, leading to JNK phosphorylation in macrophages (Nomura et al., 2013)

We then addressed whether REW could enhance antibody-mediated bacterial phagocytosis

Stanca S, Rossetti M, Bokulic Panichi L, Bongioanni P