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The supernatant was mixed with 50 l of 4M NaOH

Apr 26 2022;327(16):1577-1584

Pharmacol Ther 123:5479 Dsouza DC, Singh N, Elander J, Carbuto M, Pittman B, De Haes JU, Sjogren M, Peeters P, Ranganathan M, Schipper J (2012) Glycine transporter inhibitor attenuates the psychotomimetic effects of ketamine in healthy males: preliminary evidence

This is particularly noteworthy because two competing oral small-molecule GLP-1 programs from Pfizer, lotiglipron (discontinued in 2023) and danuglipron (discontinued in April 2025), were terminated due to liver toxicity concerns