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Description

Similarly, in SLE patients, depletion of Faecalibacterium species resulted in diminished butyrate production, attenuating its anti-inflammatory properties and thereby exacerbating both disease progression and inflammatory responses [44]

Within the cyst(e)ine/GSH/GPX4 axis, cysteine is the rate-limiting metabolite for GSH biosynthesis, hence the ferroptosis-inducing activity of cyst(e)ine depletion has largely been attributed to the lowering of intracellular GSH levels and subsequent decrease of GPX4 activity

The control variant exhibited a moderate H 2 S concentration

the present invention includes a method of treating NASH and/or fibrosis, comprising administering to a patient in need thereof a compound of Formula I, or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier