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Similarly, network pharmacology uncovered the molecular basis by which the natural compound 2-hydroxychalcone ameliorates copper sulfate-induced inflammation in zebrafish (Shen et al., 2025), and clarified how Moutan Cortex ( Paeonia suffruticosa ) exerts its anti-inflammatory and blood-activating effects via modulation of the coagulationinflammation cascadea mechanism validated across cellular, rat, and zebrafish models

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Tanaka K, Sasayama T, Irino Y, Takata K, Nagashima H, Satoh N, Kyotani K, Mizowaki T, Imahori T, Ejima Y, Masui K, Gini B, Yang H, Hosoda K, Sasaki R, Mischel PS, Kohmura E

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