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However, the success of these treatments can vary depending on the stage of the cancer at diagnosis

9.1 Consensus recommendation 9.1.1 In the presence of limited data in pediatric refractory autoimmune hepatitis, usage of salvage treatment options should be individualized based upon clinicians decision (LOE 5, Weak recommendation)

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elegans knockout model devoid of the entire coding sequence of the BBOX1 ortholog gbh-1 (ko) , and strains bearing patient-derived BBOX1 variants, including gbh-1(G283R) , gbh-1(G247Vfs*6) , and gbh-1(D72G) , which are orthologous to the human BBOX1 variants