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It is thought that KDs exert their positive effect (among others) via stimulation of mitochondrial biogenesis, improvement of mitochondrial function and decrease of oxidative stress [13,14,15,16] and therefore have been implemented in some cases with MD and epilepsy [12, 17]

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Macrophages also showed higher uptake and clearance of positively charged nanoparticles[79]

Some dogs with pyruvate kinase deficiency have sphero-echinocytes, whereas horses with G6PD or FAD deficiency may have evidence of oxidant injury (eccentrocytes, pyknocytes, Heinz bodies, methemoglobinemia)